Osteocalcin (1-49) Human (Synthetic)

V-BIOGNOSTICS Ingredients For Life_400 Research Bio-Chemicals for CofA Bestatin HCL Hydrochloride Leupeptin AEBSF G-418 Elastatinal E-64 Pepstatin Calpain Inhibitor Bleomycin Sulfate Proteinase K MG-132

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PRODUCT:  Osteocalcin (1-49), human (Synthetic)             PRODUCT NO: PNO 2100

(Cys 23 & 29 Disulfide Bridge) Acetate Salt

CAS: 136461-80-8                                                                          LOT NO:

MW: 5929.43                                                                                 STORE: -<20 Cº

Formula: C269H381N67O82S2                                       Country of Origin: Germany

1. Product information:

Appearance: white powder

Purity (HPLC 220nm): ≥95,00 %

Special: Disulfide bridge confirmed by analysis.

2.  Description: The peptide hormone osteocalcin consists of 49 amino acids and is synthesized in the bone by osteoblasts. Osteocalcin is used as a marker for bone formation and bone regeneration, as it regulates bone mineralization. The vitamin K-dependent osteocalcin synthesis is stimulated by vitamin D. Only through successful post-translational carboxylation by vitamin K is osteocalcin able to bind calcium and supply it to the bone matrix. A deficiency of vitamin K and D thus leads to a lower carboxylation, which is associated with a lower bone density and a higher risk of bone fracture. Due to its pleiotropic mechanism of action, Osteocalcin influences not only the mineralization of bones but also insulin secretion, the breakdown of fat cells and the stimulation of androgens.

3.  Stability: Stable at -20°C for 6 months.

4.  Literature:

[1] C.M. Gundberg, P.V. Hauschka, J.B. Lian, P.M. Gallop, Osteocalcin: Isolation, characterization and detection, Methods in Enzymology Vol. 107, 1984, 516-544

[2] Michael J. Power & Patrick F. Fottrell (1991) Osteocalcin: Diagnostic Methods and Clinical Applications, Critical Reviews in Clinical Laboratory Sciences, 2008, 28:4, 287-335

[3] Srivastava AK, Bhattacharyya S, Castillo G, Wergedal J, Mohan S, Baylink DJ. Development and application of a serum C-telopeptide and osteocalcin assay to measure bone turnover in an ovariectomized rat model. Calcif Tissue Int. 2000 Jun;66(6):435-42.

[4] Allison Jane Lee, Stephen Hodges, Richard Eastell, Measurement of Osteocalcin, Ann Clin Biochem, 2000, 27, 432-446

[5] Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Masato Hirata, Osteocalcin and its endocrine f unctions, Biochemical Pharmacology, 2017, Vol. 132, 1-8